759-Logic-Gated Engagers Enhance Macrophage Killing

This Nature Biotechnology article introduces a novel trispecific macrophage engager (TrME) designed to overcome the limitations of current cancer immunotherapies in solid tumors. The researchers developed a molecular "AND" logic gate that simultaneously activates the prophagocytic LRP1 receptor and blocks the inhibitory SIRPα receptor on the same macrophage. By utilizing computationally guided des...去小宇宙查看完整单集简介
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