760-Mapping Gene Cascades from Regulators to Traits

This research paper details a novel computational approach that integrates loss-of-function (LoF) genetic data with single-cell Perturb-seq experiments to map the biological pathways connecting genes to human traits. By combining quantitative trait associations from the UK Biobank with causal gene-regulatory networks in K562 cells, the authors built causal graphs that explain how genes influence c...去小宇宙查看完整单集简介
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