774-DNA Repair in R2 Retrotransposon Transgene Insertion

This research article investigates how human cells integrate R2 retrotransposons into their genome through a process called PRINT. By utilizing high-content siRNA screening, the authors identified three distinct DNA repair pathways that host cells use to convert newly synthesized cDNA into stable genes. One pathway, mediated by Polθ, utilizes microhomology to join the DNA, while a second pathway i...去小宇宙查看完整单集简介
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