785-Myofibroblast Barriers to TLS Formation in PDAC

This research identifies transforming growth factor β (TGFβ) as a major obstacle to the formation of tertiary lymphoid structures (TLSs) in pancreatic cancer. While lymphotoxin beta receptor (LTBR) signaling can trigger the development of these immune aggregates, high levels of TGFβ program fibroblasts into a myofibroblastic (myCAF) state that suppresses immune cell recruitment. By inhibiting the ...去小宇宙查看完整单集简介
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