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Paper Talk

809-CHARM: 4-Omics of Mammalian Gene Regulatory Landscape

17 min17 april 2026
Researchers have developed CHARM, a sophisticated single-cell multi-omics sequencing method that simultaneously captures four distinct layers of cellular information: gene expression, chromatin accessibility, histone modifications, and three-dimensional genome architecture. By applying this tool to mouse embryonic stem cells and brain tissues, the study provides a comprehensive map of how the 3D e...去小宇宙查看完整单集简介
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