815-Epigenomic Hijack Developmental Lineages in Ependymoma

This research identifies how the ZFTA–RELA (ZR) fusion oncoprotein drives paediatric supratentorial ependymoma by hijacking specific epigenomic states present during brain development. By comparing the developing mouse brain with human and mouse tumors, the authors discovered that ZR does not create new chromatin accessibility but instead exploits existing PLAG/L family transcription factor networ...去小宇宙查看完整单集简介
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