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Paper Talk

816-Spino-Brain-Spinal Cord Loop of Chronic Mechanical Pain

21 min18 april 2026
Researchers have identified a specialized multisynaptic circuit loop that specifically drives chronic mechanical pain while remaining inactive during normal, protective sensation. This neural pathway originates in the spinal cord, ascends through the thalamus to the primary somatosensory cortex, and returns to the spinal cord via the lateral superior colliculus and OPRM1+ neurons in the medulla. E...去小宇宙查看完整单集简介
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