821-Preventing Transgene Silencing During Differentiation

Researchers have developed the TK4 PiggyBac vector to solve the common problem of transgene silencing during the differentiation of human pluripotent stem cells. While many genetic constructs work in undifferentiated cells, they often lose functionality as those cells become mature neurons or microglia. This study identifies that combining CAG or Ubc promoters with the WPRE regulatory element effe...去小宇宙查看完整单集简介
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