822-Pathological Barriers to In Vivo Cardiac Reprogramming

Researchers have developed a Perturb-seq platform to systematically identify and rank genetic barriers that prevent the conversion of fibroblasts into functional heart muscle cells following a heart attack. By screening 140 potential inhibitors in a living mouse model, the study pinpointed calreticulin (Calr) as the primary obstacle to successful cardiac regeneration. High levels of this protein i...去小宇宙查看完整单集简介
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