836-Genetic Architecture of an Allosteric Hormone Receptor

This article introduces GluePCA, a high-throughput method used to map how thousands of mutations affect the PYL1 hormone receptor, a molecular switch in plants. By analyzing over 40,000 measurements, the researchers discovered that nearly 90% of mutations alter the receptor’s response to chemicals, primarily through changes in protein stability. The study reveals a modular genetic architecture whe...去小宇宙查看完整单集简介
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