840-MYC-USP10-SOX4 Axis in Thymocyte Development

This research identifies the deubiquitinase USP10 as a vital regulator of T cell development and a key driver of T-cell acute lymphoblastic leukemia (T-ALL). By analyzing mouse models and human clinical samples, the authors demonstrate that USP10 stabilizes the transcription factor SOX4, preventing its degradation to ensure the rapid proliferation of thymocytes. The study reveals a genetic circuit...去小宇宙查看完整单集简介
前往小宇宙评论区与主播互动