886-PerturbFate: Mapping Melanoma Drug Resistance Regulation

The paper introduces PerturbFate, a highly scalable and cost-effective single-cell platform designed to map the complex regulatory programs that drive disease phenotypes. By integrating combinatorial indexing with CRISPR interference, the method simultaneously captures chromatin accessibility, nascent transcription, and mature mRNA from individual cells. The authors demonstrate its utility by prof...去小宇宙查看完整单集简介
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