900-Orthrus: Evolutionary Functional RNA Foundation Models

The paper introduces Orthrus, a specialized RNA foundation model designed to predict the properties and functions of mature transcripts. Unlike traditional genomic models that rely on text-based learning, Orthrus utilizes a biologically inspired contrastive learning objective that leverages data from alternative splicing and evolutionary orthologs across hundreds of species. This approach allows t...去小宇宙查看完整单集简介
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