919-SMG1 Inhibition and Expansion of Cancer Immunopeptidome

The paper explores how inhibiting the nonsense-mediated mRNA decay (NMD) pathway can reveal a hidden reservoir of cancer antigens to improve immunotherapy. By targeting the SMG1 kinase, researchers successfully stabilized aberrant genetic transcripts that the body normally destroys before they can be processed by the immune system. This process reshapes the tumor immunopeptidome, introducing non-c...去小宇宙查看完整单集简介
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