944-Lecanemab attenuates Alzheimer’sAβ pathology

This research explores how the Alzheimer’s drug Lecanemab utilizes microglia to eliminate harmful amyloid-beta (Aβ) plaques from the brain. By utilizing human microglia xenograft models and spatial transcriptomics, scientists discovered that the therapy’s effectiveness depends on its Fc fragment to trigger a specific genetic program in immune cells. This program boosts phagocytosis, improves lysos...去小宇宙查看完整单集简介
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