953-Early Fibrotic Niches in Lung Tumour Initiation

This research explores how oncogenic mutations in lung stem cells initiate a self-sustaining circuit that transforms the surrounding environment before tumors fully develop. Using single-cell analysis and organoid models, scientists discovered that KrasG12D-mutant cells release a protein called amphiregulin, which triggers a fibrotic, injury-like response in neighboring fibroblasts. These reprogra...去小宇宙查看完整单集简介
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