955-ProAPOBEC: Enhanced in vivo RNA Base Editing

This research article introduces CU-REWIRE5, a pioneering RNA base editing platform that utilizes AI-assisted protein engineering to achieve precise genetic modifications. By fusing programmable PUF proteins with engineered cytidine deaminases called ProAPOBECs, the researchers expanded the targeting range to include previously difficult sequence contexts like GC, CC, and AC motifs. The study demo...去小宇宙查看完整单集简介
前往小宇宙评论区与主播互动