962-Engineered Metabolic Modulation of Gut-Liver-Brain Axis

The article details the development of genetically engineered bacteria designed to treat hepatic encephalopathy (HE) by correcting metabolic imbalances within the gut-liver-brain axis. Scientists modified the commensal strain Lactobacillus plantarum to simultaneously consume toxic ammonia, utilize L-glutamine, and produce essential branched-chain amino acids (BCAAs). In preclinical mouse models, o...去小宇宙查看完整单集简介
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