966-QuadPE: Platform for Large Genomic Insertions

The study presents QuadPE, a novel prime editing platform designed for the efficient and precise insertion of large DNA fragments into the genome. Unlike traditional methods that rely on double-stranded breaks or complex integrases, this system uses four strategically coordinated pegRNAs to guide donor DNA into specific genomic loci. Researchers demonstrated that QuadPE can integrate payloads rang...去小宇宙查看完整单集简介
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