967-Early Fibrotic Niches Establish Tumour-Permissive TME

The research explores how mutant lung stem cells actively reconstruct their surroundings to facilitate the early stages of tumor formation. By utilizing single-cell and spatial analysis, the study identifies a specific epithelial-stromal-immune circuit driven by an amphiregulin–EGFR signaling axis. This process begins when oncogenic AT2 cells adopt a regenerative state, triggering adjacent fibrobl...去小宇宙查看完整单集简介
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