971-Somatic Cancer Variants in Alzheimer’s Disease Microglia

This research demonstrates that Alzheimer's disease (AD) is linked to an increased presence of somatic cancer driver variants within the brain's immune landscape. Specifically, these genetic mutations are enriched in microglia-like brain macrophages (MLBMs), driving them toward harmful pro-inflammatory and proliferative states that mirror disease-associated signatures. Evidence suggests these muta...去小宇宙查看完整单集简介
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