987-The Metaphyseal Niche Governs Leukaemic Stem Cell Fate

The research examines how the spatial positioning of leukaemic stem cells (LSCs) within different bone marrow regions fundamentally dictates their survival and disease progression. Studies using mouse models demonstrate that LSCs remain quiescent and stem-like when localized in the metaphysis, whereas moving to the central marrow induces cell-cycle activity and therapeutic vulnerability. This loca...去小宇宙查看完整单集简介
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