990-Mechanisms of RAS Inhibitor Resistance

This research identifies how cancer cells develop resistance to tri-complex inhibitors (TCIs), which are molecular glues designed to neutralize oncogenic RAS signaling. By analyzing patient samples and preclinical models, the authors discovered that specific mutations disrupt the RAS-inhibitor-CYPA synthetic complex. Some alterations, like those at KRAS residue Y64, physically prevent the drug fro...去小宇宙查看完整单集简介
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