995-HOTSCRAMBL lncRNA: A Genetic Safeguard for Stem Cells

Researchers have identified a novel long non-coding RNA named HOTSCRAMBL, which plays a vital role in regulating human hematopoietic stem cells (HSCs). A specific inherited genetic variant, rs17437411, disrupts this RNA’s structure and impairs its ability to recruit the splicing factor SRSF2 to the HOXA9 gene. This structural failure leads to inefficient HOXA9 splicing, which reduces the self-rene...去小宇宙查看完整单集简介
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