663: Daily choices that shape brain health in your 30s, 40s & beyond | David Perlmutter, MD

“We can choose our brain’s destiny,” says David Perlmutter, MD.

Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. He is on the Board of Directors of the American College of Nutrition and the Editorial Board of the Journal of Alzheimer’s Disease. His books, including the #1 bestseller Grain Brain, has been published in 32 languages and sold over a million copies. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His new book, Brain Defenders, focuses on the pivotal role of microglia, the brain’s immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience, and is now available for pre-order.

00:00 - Treating the symptoms, not the cause 

02:37 - Microglial cells & their evil twin state 

05:44 - How metabolism affects the brain 

08:00 - Gut bacteria, inflammation, & brain degeneration 

11:38 - Why lifestyle beats the APOE4 gene 

16:25 - Perlmutter’s daily routine

23:55 - Loneliness & oxytocin 

26:21 - The effects of long COVID on the brain

32:18 - Glyphosate & other environmental factors 

39:20 - Reprogramming microglia & mitochondrial transplants 

41:35 - Own your brain's destiny

Referenced in the episode: 

For more about Perlmutter, visit his website: https://drperlmutter.com/ 

For more about Perlmutter's upcoming book, visit: https://braindefenders.com/

Alzheimers & UPFs study: https://doi.org/10.1016/j.tjpad.2024.100042 

POINTER study - https://jamanetwork.com/journals/jama/fullarticle/2837046 

20-week Alzheimer’s study: 

https://link.springer.com/article/10.1186/s13195-024-01482-z 

Golf course & Parkinson’s study: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716 

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