On a GLP-1 but Still Feeling Off? Perimenopause, HRT & Midlife Metabolism

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This isn’t medical advice — always talk to your doctor before making any health decisions.

Listener note: This episode includes candid discussion about sexual health and intimacy. Private listening is recommended if children are nearby.

For many women in their late 30s, 40s, and 50s, treating metabolic dysfunction with a GLP-1 is only part of the story. Labs may improve. Weight may shift. But sleep changes. Mood feels different. Body composition moves in unfamiliar ways. Libido quietly declines.

Perimenopause and menopause often unfold alongside metabolic treatment, and the hormonal transition can complicate everything.

In this episode, we connect midlife hormone changes with metabolic health. Dr. Cathleen “Dr. Cat” Brown, board-certified OB/GYN and Medical Director at Winona, joins us along with Kelly Miller, Winona Patient Ambassador, to discuss what’s happening during perimenopause and menopause, why hormone replacement therapy is back in the conversation, and what changed after the black box warning.

We also speak candidly about sexual health in midlife, an area that rarely gets the honesty it deserves.

For women navigating GLP-1 treatment or broader obesity care, this conversation widens the lens. Hormones matter. Context matters. And stigma around menopause deserves the same challenge as stigma around obesity.

As always, this episode is for educational purposes only and is not medical advice.

Get started with Winona 

https://start.bywinona.com/lp-menopause-care-with-winona?promocode=evergreen20&irclickid=yaKyxywNmxyKR9j1Qg0X3Rj3Uku2WWUNQXbEyw0&irgwc=1&afsrc=1&utm_

Community Guest:

Kelly Miller - Winona Patient Ambassador

Professional Guest:

Dr. Cathleen Brown

fondly known as “Dr. Cat,” is a board-certified OB/GYN with over 12 years of service as an Army physician, where she gained deep experience caring for women’s unique health needs. Today, she works as an OB laborist at Jefferson Abington Hospital near Philadelphia and serves as the Medical Director for Winona.

In her role with Winona, Dr. Cat leads bi-monthly live Q&A sessions with Chief Medical Officer, Dr. Michael Green, answering questions about menopause symptoms and treatment and diving deep into related topics. She also reviews content in Winona’s medical journal, ensuring women have access to credible medical information. She’s active on her own and Winona’s social media, connecting with her audience to offer compassion, insight, and trusted guidance. She regularly represents Winona on podcasts and at in-person events like the 2024 She Leads conference in New York City, and most recently, she was featured alongside other menopause experts in the upcoming documentary series Four Days.

Dr. Cat is passionate about educating and empowering women to take charge of their health and become advocates for themselves and their families.

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