My Plaque Protocol, and Why I Started a PCSK9 Inhibitor | Simon Hill, MSc

A few weeks ago I published my own heart scans, and one number travelled further than the rest: a 48% drop in plaque over 16 and a half months. The question underneath that video was the obvious one. How? This episode is the answer, and it is also the part I could easily have left out.

Three companies analysed the same two scans. HeartFlow found a 48% reduction, Cleerly found a 20% increase, and QAngio found essentially no change at all. Same heart, same images, and a sixfold spread in the absolute amount of plaque they measured. I walk through my full protocol, explain which analysis I anchor to and why, and tell you why, despite that headline, I have started a PCSK9 inhibitor.

What We Cover:

• Why cumulative ApoB exposure matters more than the cholesterol reading you have today
• My nutrition, training, and sleep protocol, and the supplements I deliberately avoided
• Why three platforms measuring the same heart came back with 11.5, 60, and 74 cubic millimetres
• The published concern about AI overestimation of plaque, and which analysis Dr Matthew Budoff trusts
• How my percentile swings 25 points depending on the reference database
• Why I started a PCSK9 inhibitor, and how I chose it over a statin
• Why you should be sceptical of dramatic short-interval scan results, including mine

All three analyses agreed on the thing that matters: the plaque burden is low, and it is not progressing rapidly. That agreement is worth far more than the headline.

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Simon Hill, MSc, BSc (Hons)

• Creator of theproof.com
• Host of The Proof with Simon Hill
• Author of The Proof is in the Plants

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