Training Data

OpenEvidence is transforming how doctors access medical knowledge at the point of care, from the biggest medical establishments to small practices serving rural communities. Founder Daniel Nadler explains his team’s insight that training smaller, specialized AI models on peer-reviewed literature outperforms large general models for medical applications. He discusses how making the platform freely available to all physicians led to widespread organic adoption and strategic partnerships with publishers like the New England Journal of Medicine. In an industry where organizations move glacially, 10-20% of all U.S. doctors began using OpenEvidence overnight to find information buried deep in the long tail of new medical studies, to validate edge cases and improve diagnoses. Nadler emphasizes the importance of accuracy and transparency in AI healthcare applications.

Hosted by: Pat Grady, Sequoia Capital 

Mentioned in this episode: 

• Do We Still Need Clinical Language Models?: Paper from OpenEvidence founders showing that small, specialized models outperformed large models for healthcare diagnostics
• Chinchilla paper: Seminal 2022 paper about scaling laws in large language models
• Understand: Ted Chiang sci-fi novella published in 1991

OpenAI’s Isa Fulford and Josh Tobin discuss how the company’s newest agent, Deep Research, represents a breakthrough in AI research capabilities by training models end-to-end rather than using hand-coded operational graphs. The product leads explain how high-quality training data and the o3 model’s reasoning abilities enable adaptable research strategies, and why OpenAI thinks Deep Research will capture a meaningful percentage of knowledge work. Key product decisions that build transparency and trust include citations and clarification flows. By compressing hours of work into minutes, Deep Research transforms what’s possible for many business and consumer use cases.

Hosted by: Sonya Huang and Lauren Reeder, Sequoia Capital 

Mentioned in this episode:

• Yann Lecun’s Cake: An analogy Meta AI’s leader shared in his 2016 NIPS keynote

Palo Alto Networks’s CEO Nikesh Arora dispels DeepSeek hype by detailing all of the guardrails enterprises need to have in place to give AI agents “arms and legs.” No matter the model, deploying applications for precision-use cases means superimposing better controls. Arora emphasizes that the real challenge isn’t just blocking threats but matching the accelerated pace of AI-powered attacks, requiring a fundamental shift from prevention-focused to real-time detection and response systems. CISOs are risk managers, but legacy companies competing with more risk-tolerant startups need to move quickly and embrace change. 

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

• Cortex XSIAM: Security operations and incident remediation platform from Palo Alto Networks

MongoDB product leader Sahir Azam explains how vector databases have evolved from semantic search to become the essential memory and state layer for AI applications. He describes his view of how AI is transforming software development generally, and how combining vectors, graphs and traditional data structures enables high-quality retrieval needed for mission-critical enterprise AI use cases. Drawing from MongoDB's successful cloud transformation, Azam shares his vision for democratizing AI development by making sophisticated capabilities accessible to mainstream developers through integrated tools and abstractions.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

• Introducing ambient agents: Blog post by Langchain on a new UX pattern where AI agents can listen to an event stream and act on it 
• Google Gemini Deep Research: Sahir enjoys its amazing product experience
• Perplexity: AI search app that Sahir admires for its product craft
• Snipd: AI powered podcast app Sahir likes

Stef Corazza leads generative AI development at Roblox after previously building Adobe’s 3D and AR platforms. His technical expertise, combined with Roblox’s unique relationship with its users, has led to the infusion of AI into its creation tools. Roblox has assembled the world’s largest multimodal dataset. Stef previews the Roblox Assistant and the company’s new 3D foundation model, while emphasizing the importance of maintaining positive experiences and civility on the platform. 

Mentioned in this episode:

• Driving Empire: A Roblox car racing game Stef particularly enjoys
• RDC: Roblox Developer Conference
• Ego.live: Roblox app to create and share synthetic worlds populated with human-like generative agents and simulated communities|
• PINNs: Physics Informed Neural Networks
• ControlNet: A model for controlling image diffusion by conditioning on an additional input image that Stef says can be used as a 2.5D approach to 3D generation.
• Neural rendering: A combination of deep learning with computer graphics principles developed by Nvidia in its RTX platform

Hosted by: Konstantine Buhler and Sonya Huang, Sequoia Capital

Ioannis Antonoglou, founding engineer at DeepMind and co-founder of ReflectionAI, has seen the triumphs of reinforcement learning firsthand. From AlphaGo to AlphaZero and MuZero, Ioannis has built the most powerful agents in the world. Ioannis breaks down key moments in AlphaGo's game against Lee Sodol (Moves 37 and 78), the importance of self-play and the impact of scale, reliability, planning and in-context learning as core factors that will unlock the next level of progress in AI.

Hosted by: Stephanie Zhan and Sonya Huang, Sequoia Capital

Mentioned in this episode:

• PPO: Proximal Policy Optimization algorithm developed by DeepMind in game environments. Also used by OpenAI for RLHF in ChatGPT.
• MuJoCo: Open source physics engine used to develop PPO
• Monte Carlo Tree Search: Heuristic search algorithm used in AlphaGo as well as video compression for YouTube and the self-driving system at Tesla
• AlphaZero: The DeepMind model that taught itself from scratch how to master the games of chess, shogi and Go
• MuZero: The DeepMind follow up to AlphaZero that mastered games without knowing the rules and able to plan winning strategies in unknown environments
• AlphaChem: Chemical Synthesis Planning with Tree Search and Deep Neural Network Policies
• DQN: Deep Q-Network, Introduced in 2013 paper, Playing Atari with Deep Reinforcement Learning
• AlphaFold: DeepMind model for predicting protein structures for which Demis Hassabis, John Jumper and David Baker won the 2024 Nobel Prize in Chemistry

Hema Raghavan is co-founder of Kumo, a company that makes graph neural networks accessible to enterprises by connecting to their relational data stored in Snowflake and Databricks. Hema talks about how running GNNs on GPUs has led to breakthroughs in performance as well as the query language Kumo developed to help companies predict future data points. Although approachable for non-technical users, the product provides full control for data scientists who use Kumo to automate time-consuming feature engineering pipelines.

Mentioned in this episode:

• Graph Neural Networks: Learning mechanism for data in graph format, the basis of the Kumo product
• Graph RAG: Popular extension of retrieval-augmented generation using GNNs
• LiGNN: Graph Neural Networks at LinkedIn paper 
• KDD: Knowledge Discovery and Data Mining Conference

Hosted by: Konstantine Buhler and Sonya Huang, Sequoia Capital

Berkeley professor Ion Stoica, co-founder of Databricks and Anyscale, transformed the open source projects Spark and Ray into successful AI infrastructure companies. He talks about what mattered most for Databricks' success -- the focus on making Spark win and making Databricks the best place to run Spark. He highlights the importance of striking key partnerships -- the Microsoft partnership in particular that accelerated Databricks' growth and contributed to Spark's dominance among data scientists and AI engineers. He also shares his perspective on finding new problems to work on, which holds lessons for aspiring founders and builders: 1) building systems in new areas that, if widely adopted, put you in the best position to understand the new problem space, and 2) focusing on a problem that is more important tomorrow than today.

Hosted by: Stephanie Zhan and Sonya Huang, Sequoia Capital

Mentioned in this episode: 

• Spark: The open source platform for data engineering that Databricks was originally based on.
• Ray: Open source framework to manage, executes and optimizes compute needs across AI workloads, now productized through Anyscale
• MosaicML: Generative AI startups founded by Naveen Rao that Databricks acquired in 2023.
• Unity Catalog: Data and AI governance solution from Databricks.
• CIB Berkeley: Multi-strategy hedge fund at UC Berkeley that commercializes research in the UC system.
• Hadoop: A long-time leading platform for large scale distributed computing.
• VLLM and Chatbot Arena: Two of Ion’s students’ projects that he wanted to highlight.

Oege de Moor, the creator of GitHub Copilot, discusses how XBOW’s AI offensive security system matches and even outperforms top human penetration testers, completing security assessments in minutes instead of days. The team’s speed and focus is transforming the niche market of pen testing with an always-on service-as-a-software platform. Oege describes how he is building a large and sustainable business while also creating a product that will “protect all the software in the free world.” XBOW shows how AI is essential for protecting software systems as the amount of AI-generated code increases along with the scale and sophistication of cyber threats.

Hosted by: Konstantine Buhler and Sonya Huang, Sequoia Capital

Mentioned in this episode: 

• Semmle: Oege’s previous startup, a code analysis tool to secure software, acquired in 2019 by GitHub
• Nico Waisman: Head of security at XBOW, previously a researcher at Semmle
• The Bitter Lesson: Highly influential post by Richard Sutton
• HackerOne: Cybersecurity company that runs one of the largest bug bounty programs
• Suno: AI songwriting app that Oege loves
• Machines of Loving Grace: Essay by Anthropic founder, Dario Amodei

When ChatGPT ushered in a new paradigm of AI in everyday use, many companies attempted to adapt to the new paradigm by rushing to add chat interfaces to their products. Eric has a different take—he doesn’t think chatbots are the right form factor for everything. He thinks “zero-touch” automation that works invisibly in the background can be more valuable in many cases. He cites self-driving cars as an analogy—or in this case, “self-driving money.” Ramp is a new kind of finance management company for businesses, offering AI-powered financial tools to help companies handle spending and expense processes. We’ll hear why Eric thinks AI that you never see is one of the most powerful instruments for reducing time spent on drudgery and unlocking more time for meaningful work.  

Hosted by: Ravi Gupta and Sonya Huang, Sequoia Capital

Mentioned in this episode:

• Paribus: Glyman’s previous company, acquired by Capital One in 2016
• Karim Atiyeh: Cofounder and CTO at Ramp and Glyman’s cofounder at Paribus
• Devin: AI agent product from Cognition Labs and Glyman’s favorite AI app
• Hit Refresh: Book by Satya Nadella

Founded in early 2023 after spending years at Stripe and OpenAI, Gabriel Hubert and Stanislas Polu started Dust with the view that one model will not rule them all, and that multi-model integration will be key to getting the most value out of AI assistants. In this episode we’ll hear why they believe the proprietary data you have in silos will be key to unlocking the full power of AI, get their perspective on the evolving model landscape, and how AI can augment rather than replace human capabilities.

Hosted by: Konstantine Buhler and Pat Grady, Sequoia Capital

00:00 - Introduction

02:16 - One model will not rule them all

07:15 - Reasoning breakthroughs

11:15 - Trends in AI models

13:32 - The future of the open source ecosystem

16:16 - Model quality and performance

21:44 - “No GPUs before PMF”

27:24 - Dust in action

37:40 - How do you find “the makers”

42:36 - The beliefs Dust lives by

50:03 - Keeping the human in the loop

52:33 - Second time founders

56:15 - Lightning round

Clay is leveraging AI to help go-to-market teams unleash creativity and be more effective in their work, powering custom workflows for everything from targeted outreach to personalized landing pages. It’s one of the fastest growing AI-native applications, with over 4,500 customers and 100,000 users. Founder and CEO Kareem Amin describes Clay’s technology, and its approach to balancing imagination and automation in order to help its customers achieve new levels of go-to-market success. 

Hosted by: Alfred Lin, Sequoia Capital

Can GenAI allow us to connect our imagination to what we see on our screens? Decart’s Dean Leitersdorf believes it can.

In this episode, Dean Leitersdorf breaks down how Decart is pushing the boundaries of compute in order to create AI-generated consumer experiences, from fully playable video games to immersive worlds. From achieving real-time video inference on existing hardware to building a fully vertically integrated stack, Dean explains why solving fundamental limitations rather than specific problems could lead to the next trillion-dollar company.

Hosted by: Sonya Huang and Shaun Maguire, Sequoia Capital

00:00 Introduction

03:22 About Oasis

05:25 Solving a problem vs overcoming a limitation

08:42 The role of game engines

11:15 How video real-time inference works

14:10 World model vs pixel representation

17:17 Vertical integration

34:20 Building a moat

41:35 The future of consumer entertainment

43:17 Rapid fire questions

Years before co-founding Glean, Arvind was an early Google employee who helped design the search algorithm. Today, Glean is building search and work assistants inside the enterprise, which is arguably an even harder problem. One of the reasons enterprise search is so difficult is that each individual at the company has different permissions and access to different documents and information, meaning that every search needs to be fully personalized. Solving this difficult ingestion and ranking problem also unlocks a key problem for AI: feeding the right context into LLMs to make them useful for your enterprise context. Arvind and his team are harnessing generative AI to synthesize, make connections, and turbo-change knowledge work. Hear Arvind’s vision for what kind of work we’ll do when work AI assistants reach their potential. 

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

00:00 - Introduction

08:35 - Search rankings 

11:30 - Retrieval-Augmented Generation

15:52 - Where enterprise search meets RAG

19:13 - How is Glean changing work? 

26:08 - Agentic reasoning 

31:18 - Act 2: application platform 

33:36 - Developers building on Glean 

35:54 - 5 years into the future 

38:48 - Advice for founders

In recent years there’s been an influx of theoretical physicists into the leading AI labs. Do they have unique capabilities suited to studying large models or is it just herd behavior? To find out, we talked to our former AI Fellow (and now OpenAI researcher) Dan Roberts.

Roberts, co-author of The Principles of Deep Learning Theory, is at the forefront of research that applies the tools of theoretical physics to another type of large complex system, deep neural networks. Dan believes that DLLs, and eventually LLMs, are interpretable in the same way a large collection of atoms is—at the system level. He also thinks that emphasis on scaling laws will balance with new ideas and architectures over time as scaling asymptotes economically.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

• The Principles of Deep Learning Theory: An Effective Theory Approach to Understanding Neural Networks, by Daniel A. Roberts, Sho Yaida, Boris Hanin
• Black Holes and the Intelligence Explosion: Extreme scenarios of AI focus on what is logically possible rather than what is physically possible. What does physics have to say about AI risk?
• Yang-Mills & The Mass Gap: An unsolved Millennium Prize problem

AI Math Olympiad: Dan is on the prize committee

NotebookLM from Google Labs has become the breakout viral AI product of the year. The feature that catapulted it to viral fame is Audio Overview, which generates eerily realistic two-host podcast audio from any input you upload—written doc, audio or video file, or even a PDF. But to describe NotebookLM as a “podcast generator” is to vastly undersell it. The real magic of the product is in offering multi-modal dimensions to explore your own content in new ways—with context that’s surprisingly additive. 200-page training manuals become synthesized into digestible chapters, turned into a 10-minute podcast—or both—and shared with the sales team, just to cite one example. Raiza Martin and Jason Speilman join us to discuss how the magic happens, and what’s next for source-grounded AI.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital

All of us as consumers have felt the magic of ChatGPT—but also the occasional errors and hallucinations that make off-the-shelf language models problematic for business use cases with no tolerance for errors. Case in point: A model deployed to help create a summary for this episode stated that Sridhar Ramaswamy previously led PyTorch at Meta. He did not. He spent years running Google’s ads business and now serves as CEO of Snowflake, which he describes as the data cloud for the AI era.

Ramaswamy discusses how smart systems design helped Snowflake create reliable "talk-to-your-data" applications with over 90% accuracy, compared to around 45% for out-of-the-box solutions using off the shelf LLMs. He describes Snowflake's commitment to making reliable AI simple for their customers, turning complex software engineering projects into straightforward tasks. 

Finally, he stresses that even as frontier models progress, there is significant value to be unlocked from current models by applying them more effectively across various domains.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital

Mentioned in this episode: 

Cortex Analyst: Snowflake’s talk-to-your-data API

Document AI: Snowflake feature that extracts in structured information from documents

Combining LLMs with AlphaGo-style deep reinforcement learning has been a holy grail for many leading AI labs, and with o1 (aka Strawberry) we are seeing the most general merging of the two modes to date. o1 is admittedly better at math than essay writing, but it has already achieved SOTA on a number of math, coding and reasoning benchmarks.

Deep RL legend and now OpenAI researcher Noam Brown and teammates Ilge Akkaya and Hunter Lightman discuss the ah-ha moments on the way to the release of o1, how it uses chains of thought and backtracking to think through problems, the discovery of strong test-time compute scaling laws and what to expect as the model gets better. 

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

• Learning to Reason with LLMs: Technical report accompanying the launch of OpenAI o1.
• Generator verifier gap: Concept Noam explains in terms of what kinds of problems benefit from more inference-time compute.
• Agent57: Outperforming the human Atari benchmark, 2020 paper where DeepMind demonstrated “the first deep reinforcement learning agent to obtain a score that is above the human baseline on all 57 Atari 2600 games.”
• Move 37: Pivotal move in AlphaGo’s second game against Lee Sedol where it made a move so surprising that Sedol thought it must be a mistake, and only later discovered he had lost the game to a superhuman move.
• IOI competition: OpenAI entered o1 into the International Olympiad in Informatics and received a Silver Medal.
• System 1, System 2: The thesis if Danial Khaneman’s pivotal book of behavioral economics, Thinking, Fast and Slow, that positied two distinct modes of thought, with System 1 being fast and instinctive and System 2 being slow and rational.
• AlphaZero: The predecessor to AlphaGo which learned a variety of games completely from scratch through self-play. Interestingly, self-play doesn’t seem to have a role in o1.
• Solving Rubik’s Cube with a robot hand: Early OpenAI robotics paper that Ilge Akkaya worked on.
• The Last Question: Science fiction story by Isaac Asimov with interesting parallels to scaling inference-time compute.
• Strawberry: Why?
• O1-mini: A smaller, more efficient version of 1 for applications that require reasoning without broad world knowledge.

00:00 - Introduction

01:33 - Conviction in o1

04:24 - How o1 works

05:04 - What is reasoning?

07:02 - Lessons from gameplay

09:14 - Generation vs verification

10:31 - What is surprising about o1 so far

11:37 - The trough of disillusionment

14:03 - Applying deep RL

14:45 - o1’s AlphaGo moment?

17:38 - A-ha moments

21:10 - Why is o1 good at STEM?

24:10 - Capabilities vs usefulness

25:29 - Defining AGI

26:13 - The importance of reasoning

28:39 - Chain of thought

30:41 - Implication of inference-time scaling laws

35:10 - Bottlenecks to scaling test-time compute

38:46 - Biggest misunderstanding about o1?

41:13 - o1-mini

42:15 - How should founders think about o1?

Adding code to LLM training data is a known method of improving a model’s reasoning skills. But wouldn’t math, the basis of all reasoning, be even better? Up until recently, there just wasn’t enough usable data that describes mathematics to make this feasible.

A few years ago, Vlad Tenev (also founder of Robinhood) and Tudor Achim noticed the rise of the community around an esoteric programming language called Lean that was gaining traction among mathematicians. The combination of that and the past decade’s rise of autoregressive models capable of fast, flexible learning made them think the time was now and they founded Harmonic. Their mission is both lofty—mathematical superintelligence—and imminently practical, verifying all safety-critical software.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

• IMO and the Millennium Prize: Two significant global competitions Harmonic hopes to win (soon)
• Riemann hypothesis: One of the most difficult unsolved math conjectures (and a Millenium Prize problem) most recently in the sights of MIT mathematician Larry Guth
• Terry Tao: perhaps the greatest living mathematician and Vlad’s professor at UCLA
• Lean: an open source functional language for code verification launched by Leonardo de Moura when at Microsoft Research in 2013 that powers the Lean Theorem Prover
• mathlib: the largest math textbook in the world, all written in Lean
• Metaculus: online prediction platform that tracks and scores thousands of forecasters
• Minecraft Beaten in 20 Seconds: The video Vlad references as an analogy to AI math
• Navier-Stokes equations: another important Millenium Prize math problem. Vlad considers this more tractable that Riemann
• John von Neumann: Hungarian mathematician and polymath that made foundational contributions to computing, the Manhattan Project and game theory
• Gottfried Wilhelm Leibniz: co-inventor of calculus and (remarkably) creator of the “universal characteristic,” a system for reasoning through a language of symbols and calculations—anticipating Lean and Harmonic by 350 years!

00:00 - Introduction

01:42 - Math is reasoning

06:16 - Studying with the world's greatest living mathematician

10:18 - What does the math community think of AI math?

15:11 - Recursive self-improvement

18:31 - What is Lean?

21:05 - Why now?

22:46 - Synthetic data is the fuel for the model

27:29 - How fast will your model get better?

29:45 - Exploring the frontiers of human knowledge

34:11 - Lightning round

AI researcher Jim Fan has had a charmed career. He was OpenAI’s first intern before he did his PhD at Stanford with “godmother of AI,” Fei-Fei Li. He graduated into a research scientist position at Nvidia and now leads its Embodied AI “GEAR” group. The lab’s current work spans foundation models for humanoid robots to agents for virtual worlds.

Jim describes a three-pronged data strategy for robotics, combining internet-scale data, simulation data and real world robot data. He believes that in the next few years it will be possible to create a “foundation agent” that can generalize across skills, embodiments and realities—both physical and virtual. He also supports Jensen Huang’s idea that “Everything that moves will eventually be autonomous.”

Hosted by: Stephanie Zhan and Sonya Huang, Sequoia Capital

Mentioned in this episode:

• World of Bits: Early OpenAI project Jim worked on as an intern with Andrej Karpathy. Part of a bigger initiative called Universe
• Fei-Fei Li: Jim’s PhD advisor at Stanford who founded the ImageNet project in 2010 that revolutionized the field of visual recognition, led the Stanford Vision Lab and just launched her own AI startup, World Labs
• Project GR00T: Nvidia’s “moonshot effort” at a robotic foundation model, premiered at this year’s GTC
• Thinking Fast and Slow: Influential book by Daniel Kahneman that popularized some of his teaching from behavioral economics
• Jetson Orin chip: The dedicated series of edge computing chips Nvidia is developing to power Project GR00T
• Eureka: Project by Jim’s team that trained a five finger robot hand to do pen spinning
• MineDojo: A project Jim did when he first got to Nvidia that developed a platform for general purpose agents in the game of Minecraft. Won NeurIPS 2022 Outstanding Paper Award
• ADI: artificial dog intelligence
• Mamba: Selective State Space Models, an alternative architecture to Transformers that Jim is interested in (original paper here)

00:00 Introduction

01:35 Jim’s journey to embodied intelligence

04:53 The GEAR Group

07:32 Three kinds of data for robotics

10:32 A GPT-3 moment for robotics

16:05 Choosing the humanoid robot form factor

19:37 Specialized generalists

21:59 GR00T gets its own chip

23:35 Eureka and Issac Sim

25:23 Why now for robotics?

28:53 Exploring virtual worlds

36:28 Implications for games

39:13 Is the virtual world in service of the physical world?

42:10 Alternative architectures to Transformers

44:15 Lightning round

There’s a new archetype in Silicon Valley, the AI researcher turned founder. Instead of tinkering in a garage they write papers that earn them the right to collaborate with cutting-edge labs until they break out and start their own.

This is the story of wunderkind Eric Steinberger, the founder and CEO of Magic.dev. Eric came to programming through his obsession with AI and caught the attention of DeepMind researchers as a high school student. In 2022 he realized that AGI was closer than he had previously thought and started Magic to automate the software engineering necessary to get there. Among his counterintuitive ideas are the need to train proprietary large models, that value will not accrue in the application layer and that the best agents will manage themselves. Eric also talks about Magic’s recent 100M token context window model and the HashHop eval they’re open sourcing.

Hosted by: Sonya Huang, Sequoia Capital

Mentioned in this episode:

• David Silver: DeepMind researcher that led the AlphaGo team
• Johannes Heinrich: a PhD student of Silver’s and DeepMind researcher who mentored Eric as a highschooler
• Reinforcement Learning from Self-Play in Imperfect-Information Games: Johannes’s dissertation that inspired Eric 
• Noam Brown: DeepMind, Meta and now OpenAI reinforcement learning researcher who eventually collaborated with Eric and brought him to FAIR
• ClimateScience: NGO that Eric co-founded in 2019 while a university student 
• Noam Shazeer: One of the original Transformers researchers at Google and founder of Charater.ai 
• DeepStack: Expert-Level Artificial Intelligence in Heads-Up No-Limit Poker: the first AI paper Eric ever tried to deeply understand
• LTM-2-mini: Magic’s first 100M token context model, build using the HashHop eval (now available open source)

00:00 - Introduction

01:39 - Vienna-born wunderkind

04:56 - Working with Noam Brown

8:00 - “I can do two things. I cannot do three.”

10:37 - AGI to-do list

13:27 - Advice for young researchers

20:35 - Reading every paper voraciously

23:06 - The army of Noams

26:46 - The leaps still needed in research

29:59 - What is Magic?

36:12 - Competing against the 800-pound gorillas

38:21 - Ideal team size for researchers

40:10 - AI that feels like a colleague

44:30 - Lightning round

47:50 - Bonus round: 200M token context announcement

On Training Data, we learn from innovators pushing forward the frontier of AI’s capabilities. Today we’re bringing you something different. It’s the story of a company currently implementing AI at scale in the enterprise, and how it was built from a bootstrapped idea in the pre-AI era to a 150 billion dollar market cap giant. 

It’s the Season 2 premiere of Sequoia’s other podcast, Crucible Moments, where we hear from the founders and leaders of some legendary companies about the crossroads and inflection points that shaped their journeys. In this episode, you’ll hear from Fred Luddy and Frank Slootman about building and scaling ServiceNow. Listen to Crucible Moments wherever you get your podcasts or go to:

Spotify: https://open.spotify.com/show/40bWCUSan0boCn0GZJNpPn

Apple: https://podcasts.apple.com/us/podcast/crucible-moments/id1705282398

Hosted by: Roelof Botha, Sequoia Capital

Transcript: https://www.sequoiacap.com/podcast/crucible-moments-servicenow/

Customer service is hands down the first killer app of generative AI for businesses. The reasons are simple: the costs of existing solutions are so high, the satisfaction so low and the margin for ROI so wide. But trusting your interactions with customers to hallucination-prone LLMs can be daunting.

Enter Sierra. Co-founder Clay Bavor walks us through the sophisticated engineering challenges his team solved along the way to delivering AI agents for all aspects of the customer experience that are delightful, safe and reliable—and being deployed widely by Sierra’s customers. The Company’s AgentOS enables businesses to create branded AI agents to interact with customers, follow nuanced policies and even handle customer retention and upsell. Clay describes how companies can capture their brand voice, values and internal processes to create AI agents that truly represent the business.

Hosted by: Ravi Gupta and Pat Grady, Sequoia Capital

Mentioned in this episode:

• Bret Taylor: co-founder of Sierra
• Towards a Human-like Open-Domain Chatbot: 2020 Google paper that introduced Meena, a predecessor of ChatGPT (followed by LaMDA in 2021)
• PaLM: Scaling Language Modeling with Pathways: 2022 Google paper about their unreleased 540B parameter transformer model (GPT-3, at the time, had 175B) 
• Avocado chair: Images generated by OpenAI’s DALL·E model in 2022
• Large Language Models Understand and Can be Enhanced by Emotional Stimuli: 2023 Microsoft paper on how models like GPT-4 can be manipulated into providing better results
• 𝛕-bench: A Benchmark for Tool-Agent-User Interaction in Real-World Domains: 2024 paper authored by Sierra research team, led by Karthik Narasimhan (co-author of the 2022 ReACT paper and the 2023 Reflexion paper)

00:00:00 Introduction

00:01:21 Clay’s background

00:03:20 Google before the ChatGPT moment

00:07:31 What is Sierra?

00:12:03 What’s possible now that wasn’t possible 18 months ago?

00:17:11 AgentOS

00:23:45 The solution to many problems with AI is more AI

00:28:37 𝛕-bench

00:33:19 Engineering task vs research task

00:37:27 What tasks can you trust an agent with now?

00:43:21 What metrics will move?

00:46:22 The reality of deploying AI to customers today

00:53:33 The experience manager

01:03:54 Outcome-based pricing

01:05:55 Lightning Round

After AlphaGo beat Lee Sedol, a young mechanical engineer at Google thought of another game reinforcement learning could win: energy optimization at data centers. Jim Gao convinced his bosses at the Google data center team to let him work with the DeepMind team to try. The initial pilot resulted in a 40% energy savings and led he and his co-founders to start Phaidra to turn this technology into a product.

Jim discusses the challenges of AI readiness in industrial settings and how we have to build on top of the control systems of the 70s and 80s to achieve the promise of the Fourth Industrial Revolution. He believes this new world of self-learning systems and self-improving infrastructure is a key factor in addressing global climate change.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

• Mustafa Suleyman: Co-founder of DeepMind and Inflection AI and currently CEO of Microsoft AI, known to his friends as “Moose”
• Joe Kava: Google VP of data centers who Jim sent his initial email to pitching the idea that would eventually become Phaidra
• Constrained optimization: the class of problem that reinforcement learning can be applied to in real world systems 
• Vedavyas Panneershelvam: co-founder and CTO of Phaidra; one of the original engineers on the AlphaGo project
• Katie Hoffman: co-founder, President and COO of Phaidra 
• Demis Hassabis: CEO of DeepMind

In the first wave of the generative AI revolution, startups and enterprises built on top of the best closed-source models available, mostly from OpenAI. The AI customer journey moves from training to inference, and as these first products find PMF, many are hitting a wall on latency and cost.

Fireworks Founder and CEO Lin Qiao led the PyTorch team at Meta that rebuilt the whole stack to meet the complex needs of the world’s largest B2C company. Meta moved PyTorch to its own non-profit foundation in 2022 and Lin started Fireworks with the mission to compress the timeframe of training and inference and democratize access to GenAI beyond the hyperscalers to let a diversity of AI applications thrive.

Lin predicts when open and closed source models will converge and reveals her goal to build simple API access to the totality of knowledge.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

• Pytorch: the leading framework for building deep learning models, originated at Meta and now part of the Linux Foundation umbrella
• Caffe2 and ONNX: ML frameworks Meta used that PyTorch eventually replaced
• Conservation of complexity: the idea that that every computer application has inherent complexity that cannot be reduced but merely moved between the backend and frontend, originated by Xerox PARC researcher Larry Tesler 
• Mixture of Experts: a class of transformer models that route requests between different subsets of a model based on use case
• Fathom: a product the Fireworks team uses for video conference summarization 
• LMSYS Chatbot Arena: crowdsourced open platform for LLM evals hosted on Hugging Face

 00:00 - Introduction

02:01 - What is Fireworks?

02:48 - Leading Pytorch

05:01 - What do researchers like about PyTorch?

07:50 - How Fireworks compares to open source

10:38 - Simplicity scales

12:51 - From training to inference

17:46 - Will open and closed source converge?

22:18 - Can you match OpenAI on the Fireworks stack?

26:53 - What is your vision for the Fireworks platform?

31:17 - Competition for Nvidia?

32:47 - Are returns to scale starting to slow down?

34:28 - Competition

36:32 - Lightning round

GithHub invented collaborative coding and in the process changed how open source projects, startups and eventually enterprises write code. GitHub Copilot is the first blockbuster product built on top of OpenAI’s GPT models. It now accounts for more than 40 percent of GitHub revenue growth for an annual revenue run rate of $2 billion. Copilot itself is already a larger business than all of GitHub was when Microsoft acquired it in 2018.

We talk to CEO Thomas Dohmke about how a small team at GitHub built on top of GPT-3 and quickly created a product that developers love—and can’t live without. Thomas describes how the product has grown from simple autocomplete to a fully featured workspace for enterprise teams. He also believes that tools like Copilot will bring the power of coding to a billion developers by 2030.

Hosted by: Stephanie Zhan and Sonya Huang, Sequoia Capital 

Mentioned in this episode:

• Nat Friedman: Former Microsoft VP (and now investor) who came up with the idea that Microsoft should buy GitHub
• Oege de Moor: Github developer (and now founder of XBOW) who came up with the idea of using GPT-3 for code and went on to create Copilot
• Alex Graveley: principal engineer and Chief Architect for Copilot (now CEO of Minion.ai) who came up with the name Copilot (because his boss, Nat Firedman, is an amateur pilot)
• Productivity Assessment of Neural Code Completion: Original GitHub research paper on the impact of Copilot on Developer productivity
• Escaping a room in Minecraft with an AI-powered NPC: Recent Minecraft AI assistant demo from Microsoft
• With AI, anyone can be a coder now: TED2024 talk by Thomas Dohmke
• JFrog: The software supply chain platform that GitHub just partnered with

00:00:00 - Introduction

00:01:18 - Getting started with code

00:03:43 - Microsoft’s acquisition of GitHub

00:11:40 - Evolving Copilot beyond autocomplete

00:14:18 - In hindsight, you can always move faster

00:15:56 - Building on top of OpenAI

00:20:21 - The latest metrics

00:22:11 - The surprise of Copilot’s impact

00:25:11 - Teaching kids to code in the age of Copilot

00:26:38 - The momentum mindset

00:29:46 - Agents vs Copilots

00:32:06 - The Roadmap

00:37:31 - Making maintaining software easier

00:38:48 - The creative new world

00:42:38 - The AI 10x software engineer

00:45:12 - Creativity and systems engineering in AI

00:48:55 - What about COBOL?

00:50:23 - Will GitHub build its own models?

00:57:19 - Rapid incubation at GitHub Next

00:59:21 - The future of AI?

01:03:18 - Advice for founders

01:05:08 - Lightning round

As head of Product Management for Generative AI at Meta, Joe Spisak leads the team behind Llama, which just released the new 3.1 405B model. We spoke with Joe just two days after the model’s release to ask what’s new, what it enables, and how Meta sees the role of open source in the AI ecosystem.

Joe shares that where Llama 3.1 405B really focused is on pushing scale (it was trained on 15 trillion tokens using 16,000 GPUs) and he’s excited about the zero-shot tool use it will enable, as well as its role in distillation and generating synthetic data to teach smaller models. He tells us why he thinks even frontier models will ultimately commoditize—and why that’s a good thing for the startup ecosystem.

Hosted by: Stephanie Zhan and Sonya Huang, Sequoia Capital 

Mentioned in this episode: 

Llama 3.1 405B paper

Open Source AI Is the Way Forward: Mark Zuckerberg essay released with Llama 3.1.

Mistral Large 2

The Bitter Lesson by Rich Sutton

00:00 Introduction

01:28 The Llama 3.1 405B launch

05:02 The open source license

07:01 What's in it for Meta?

10:19 Why not open source?

11:16 Will frontier models commoditize?

12:41 What about startups?

16:29 The Mistral team

19:36 Are all frontier strategies comparable?

22:38 Is model development becoming more like software development?

26:34 Agentic reasoning

29:09 What future levers will unlock reasoning?

31:20 Will coding and math lead to unlocks?

33:09 Small models

34:08 7X more data

37:36 Are we going to hit a wall?

39:49 Lightning round

In February, Sebastian Siemiatkowski boldly announced that Klarna’s new OpenAI-powered assistant handled two thirds of the Swedish fintech’s customer service chats in its first month. Not only were customer satisfaction metrics better, but by replacing 700 full-time contractors the bottom line impact is projected to be $40M. Since then, every company we talk to wants to know, “How do we get the Klarna customer support thing?”

Co-founder and CEO Sebastian Siemiatkowski tells us how the Klarna team shipped this new product in record time—and how embracing AI internally with an experimental mindset is transforming the company. He discusses how AI development is proliferating inside the company, from customer support to marketing to internal knowledge to customer-facing experiences. 

Sebastian also reflects on the impacts of AI on employment, society, and the arts while encouraging lawmakers to be open minded about the benefits.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned in this episode:

DeepL: Language translation app that Sebastian says makes 10,000 translators in Brussels redundant

The Klarna brand: The offbeat optimism that the company is now augmenting with AI

Neo4j: The graph database management system that Klarna is using to build Kiki, their internal knowledge base

00:00 Introduction

01:57 Klarna’s business

03:00 Pitching OpenAI

08:51 How we built this

10:46 Will Klara ever completely replace its CS team with AI?

14:22 The benefits

17:25 If you had a policy magic wand…

21:12 What jobs will be most affected by AI?

23:58 How about marketing?

27:55 How creative are LLMs?

30:11 Klarna’s knowledge graph, Kiki

33:10 Reducing the number of enterprise systems

35:24 Build vs buy?

39:59 What’s next for Klarna with AI?

48:48 Lightning round

LLMs are democratizing digital intelligence, but we’re all waiting for AI agents to take this to the next level by planning tasks and executing actions to actually transform the way we work and live our lives. 

Yet despite incredible hype around AI agents, we’re still far from that “tipping point” with best in class models today. As one measure: coding agents are now scoring in the high-teens % on the SWE-bench benchmark for resolving GitHub issues, which far exceeds the previous unassisted baseline of 2% and the assisted baseline of 5%, but we’ve still got a long way to go.

Why is that? What do we need to truly unlock agentic capability for LLMs? What can we learn from researchers who have built both the most powerful agents in the world, like AlphaGo, and the most powerful LLMs in the world? 

To find out, we’re talking to Misha Laskin, former research scientist at DeepMind. Misha is embarking on his vision to build the best agent models by bringing the search capabilities of RL together with LLMs at his new company, Reflection AI. He and his cofounder Ioannis Antonoglou, co-creator of AlphaGo and AlphaZero and RLHF lead for Gemini, are leveraging their unique insights to train the most reliable models for developers building agentic workflows.

Hosted by: Stephanie Zhan and Sonya Huang, Sequoia Capital 

00:00 Introduction

01:11 Leaving Russia, discovering science

10:01 Getting into AI with Ioannis Antonoglou

15:54 Reflection AI and agents

25:41 The current state of Ai agents

29:17 AlphaGo, AlphaZero and Gemini

32:58 LLMs don’t have a ground truth reward

37:53 The importance of post-training

44:12 Task categories for agents

45:54 Attracting talent

50:52 How far away are capable agents?

56:01 Lightning round

Mentioned: 

• The Feynman Lectures on Physics: The classic text that got Misha interested in science.
• Mastering the game of Go with deep neural networks and tree search: The original 2016 AlphaGo paper.
• Mastering the game of Go without human knowledge: 2017 AlphaGo Zero paper
• Scaling Laws for Reward Model Overoptimization: OpenAI paper on how reward models can be gamed at all scales for all algorithms.
• Mapping the Mind of a Large Language Model: Article about Anthropic mechanistic interpretability paper that identifies how millions of concepts are represented inside Claude Sonnet
• Pieter Abeel: Berkeley professor and founder of Covariant who Misha studied with
• A2C and A3C: Advantage Actor Critic and Asynchronous Advantage Actor Critic, the two algorithms developed by Misha’s manager at DeepMind, Volodymyr Mnih, that defined reinforcement learning and deep reinforcement learning

The current LLM era is the result of scaling the size of models in successive waves (and the compute to train them). It is also the result of better-than-Moore’s-Law price vs performance ratios in each new generation of Nvidia GPUs. The largest platform companies are continuing to invest in scaling as the prime driver of AI innovation.

Are they right, or will marginal returns level off soon, leaving hyperscalers with too much hardware and too few customer use cases? To find out, we talk to Microsoft CTO Kevin Scott who has led their AI strategy for the past seven years. Scott describes himself as a “short-term pessimist, long-term optimist” and he sees the scaling trend as durable for the industry and critical for the establishment of Microsoft’s AI platform.

Scott believes there will be a shift across the compute ecosystem from training to inference as the frontier models continue to improve, serving wider and more reliable use cases. He also discusses the coming business models for training data, and even what ad units might look like for autonomous agents.

Hosted by: Pat Grady and Bill Coughran, Sequoia Capital

Mentioned:

BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding, the 2018 Google paper that convinced Kevin that Microsoft wasn’t moving fast enough on AI. 

Dennard scaling: The scaling law that describes the proportional relationship between transistor size and power use; has not held since 2012 and is often confused with Moore’s Law.

Textbooks Are All You Need: Microsoft paper that introduces a new large language model for code, phi-1, that achieves smaller size by using higher quality “textbook” data.

GPQA and MMLU: Benchmarks for reasoning

Copilot: Microsoft product line of GPT consumer assistants from general productivity to design, vacation planning, cooking and fitness.

Devin: Autonomous AI code agent from Cognition Labs that Microsoft recently announced a partnership with.

Ray Solomonoff: Participant in the 1956 Dartmouth Summer Research Project on Artificial Intelligence that named the field; Kevin admires his prescience about the importance of probabilistic methods decades before anyone else.

00:00 - Introduction

01:20 - Kevin’s backstory

06:56 - The role of PhDs in AI engineering

09:56 - Microsoft’s AI strategy

12:40 - Highlights and lowlights

16:28 - Accelerating investments

18:38 - The OpenAI partnership

22:46 - Soon inference will dwarf training

27:56 - Will the demand/supply balance change?

30:51 - Business models for data

36:54 - The value function

39:58 - Copilots

44:47 - The 98/2 rule

49:34 - Solving zero-sum games

57:13 - Lightning round

As impressive as LLMs are, the growing consensus is that language, scale and compute won’t get us to AGI. Although many AI benchmarks have quickly achieved human-level performance, there is one eval that has barely budged since it was created in 2019.

Google researcher François Chollet wrote a paper that year defining intelligence as skill-acquisition efficiency—the ability to learn new skills as humans do, from a small number of examples. To make it testable he proposed a new benchmark, the Abstraction and Reasoning Corpus (ARC), designed to be easy for humans, but hard for AI. Notably, it doesn’t rely on language.

Zapier co-founder Mike Knoop read Chollet’s paper as the LLM wave was rising. He worked quickly to integrate generative AI into Zapier’s product, but kept coming back to the lack of progress on the ARC benchmark. In June, Knoop and Chollet launched the ARC Prize, a public competition offering more than $1M to beat and open-source a solution to the ARC-AGI eval.

In this episode Mike talks about the new ideas required to solve ARC, shares updates from the first two weeks of the competition, and shares why he’s excited for AGI systems that can innovate alongside humans.

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned:

• Chain-of-Thought Prompting Elicits Reasoning in Large Language Models: The 2019 paper that first caught Mike’s attention about the capabilities of LLMs
• On the Measure of Intelligence: 2019 paper by Google researcher François Chollet that introduced the ARC benchmark, which remains unbeaten
• ARC Prize 2024: The $1M+ competition Mike and François have launched to drive interest in solving the ARC-AGI eval
• Sequence to Sequence Learning with Neural Networks: Ilya Sutskever paper from 2014 that influenced the direction of machine translation with deep neural networks.
• Etched: Luke Miles on LessWrong wrote about the first ASIC chip that accelerates transformers on silicon
• Kaggle: The leading data science competition platform and online community, acquired by Google in 2017
• Lab42: Swiss AU lab that hosted ARCathon precursor to ARC Prize
• Jack Cole: Researcher on team that was #1 on the leaderboard for ARCathon
• Ryan Greenblatt: Researcher with current high score (50%) on ARC public leaderboard

(00:00) Introduction

(01:51) AI at Zapier

(08:31) What is ARC AGI?

(13:25) What does it mean to efficiently acquire a new skill?

(19:03) What approaches will succeed?

(21:11) A little bit of a different shape

(25:59) The role of code generation and program synthesis

(29:11) What types of people are working on this?

(31:45) Trying to prove you wrong

(34:50) Where are the big labs?

(38:21) The world post-AGI

(42:51) When will we cross 85% on ARC AGI?

(46:12) Will LLMs be part of the solution?

(50:13) Lightning round

Archimedes said that with a large enough lever, you can move the world. For decades, software engineering has been that lever. And now, AI is compounding that lever. How will we use AI to apply 100 or 1000x leverage to the greatest lever to move the world?

Matan Grinberg and Eno Reyes, co-founders of Factory, have chosen to do things differently than many of their peers in this white-hot space. They sell a fleet of “Droids,” purpose-built dev agents which accomplish different tasks in the software development lifecycle (like code review, testing, pull requests or writing code). Rather than training their own foundation model, their approach is to build something useful for engineering orgs today on top of the rapidly improving models, aligning with the developer and evolving with them. 

Matan and Eno are optimistic about the effects of autonomy in software development and on building a company in the application layer. Their advice to founders, “The only way you can win is by executing faster and being more obsessed.”

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital 

Mentioned: 

• Juan Maldacena, Institute for Advanced Study, string theorist that Matan cold called as an undergrad
• SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering, small-model open-source software engineering agent
• SWE-bench: Can Language Models Resolve Real-World GitHub Issues?, an evaluation framework for GitHub issues
• Monte Carlo tree search, a 2006 algorithm for solving decision making in games (and used in AlphaGo)
• Language agent tree search, a framework for LLM planning, acting and reasoning
• The Bitter Lesson, Rich Sutton’s essay on scaling in search and learning 
• Code churn, time to merge, cycle time, metrics Factory thinks are important to eng orgs

Transcript: https://www.sequoiacap.com/podcast/training-data-factory/

00:00 Introduction

01:36 Personal backgrounds

10:54 The compound lever

12:41 What is Factory? 

16:29 Cognitive architectures 

21:13 800 engineers at OpenAI are working on my margins 

24:00 Jeff Dean doesn't understand your code base

25:40 Individual dev productivity vs system-wide optimization 

30:04 Results: Factory in action 

32:54 Learnings along the way 

35:36 Fully autonomous Jeff Deans

37:56 Beacons of the upcoming age

40:04 How far are we? 

43:02 Competition 

45:32 Lightning round

49:34 Bonus round: Factory's SWE-bench results

Last year, AutoGPT and Baby AGI captured our imaginations—agents quickly became the buzzword of the day…and then things went quiet. AutoGPT and Baby AGI may have marked a peak in the hype cycle, but this year has seen a wave of agentic breakouts on the product side, from Klarna’s customer support AI to Cognition’s Devin, etc.

Harrison Chase of LangChain is focused on enabling the orchestration layer for agents. In this conversation, he explains what’s changed that’s allowing agents to improve performance and find traction. 

Harrison shares what he’s optimistic about, where he sees promise for agents vs. what he thinks will be trained into models themselves, and discusses novel kinds of UX that he imagines might transform how we experience agents in the future.     

Hosted by: Sonya Huang and Pat Grady, Sequoia Capital

Mentioned: 

• ReAct: Synergizing Reasoning and Acting in Language Models, the first cognitive architecture for agents
• SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering, small-model open-source software engineering agent from researchers at Princeton
• Devin, autonomous software engineering from Cognition
• V0: Generative UI agent from Vercel
• GPT Researcher, a research agent 
• Language Model Cascades: 2022 paper by Google Brain and now OpenAI researcher David Dohan that was influential for Harrison in developing LangChain

Transcript: https://www.sequoiacap.com/podcast/training-data-harrison-chase/

00:00 Introduction

01:21 What are agents? 

05:00 What is LangChain’s role in the agent ecosystem?

11:13 What is a cognitive architecture? 

13:20 Is bespoke and hard coded the way the world is going, or a stop gap?

18:48 Focus on what makes your beer taste better

20:37 So what? 

22:20 Where are agents getting traction?

25:35 Reflection, chain of thought, other techniques?

30:42 UX can influence the effectiveness of the architecture

35:30 What’s out of scope?

38:04 Fine tuning vs prompting?

42:17 Existing observability tools for LLMs vs needing a new architecture/approach

45:38 Lightning round

Join us as we train our neural nets on the theme of the century: AI. Sequoia Capital partners Sonya Huang and Pat Grady host conversations with leading AI builders and researchers to ask critical questions and develop a deeper understanding of the evolving technologies and their implications for technology, business and society.

The content of this podcast does not constitute investment advice, an offer to provide investment advisory services, or an offer to sell or solicitation of an offer to buy an interest in any investment fund.